STUDIES AVAILABLE OF
1.Adult syncytial giant cell chronic hepatitis due to herbal remedy.
Fraquelli M, Colli A, Cocciolo M, Conte D.
Cattedra di Gastroenterologia, IRCCS Ospedale Maggiore, Milan, Italy.
Syncytial giant cell hepatitis is an uncommon form of chronic hepatitis in adults, although it has been reported in association with viral infection (including HCV and HIV infection), drug reactions and autoimmune disorders. We here report a very unusual case of giant cell chronic hepatitis in a 26-old-woman, who had been taking a herbal remedy (ISABGOL) for chronic constipation. The presence of viral and metabolic diseases has been excluded; an autoimmune etiology was very unlikely as the autoimmunity test remained negative during the year of follow-up and the total disease score normalized (from 13 to 8) without corticosteroid treatment. The causative role of the herbal remedy was further supported by the spontaneous and dramatic clinical, biochemical and histologic improvement observed following its withdrawal, despite the absence of any treatment.
Publication Types: PMID: 11020009 [PubMed - indexed for MEDLINE]
2.Maternal beliefs and practices regarding the diet and use of herbal medicines during measles and diarrhea in rural areas.
Desert Medicine Research Center (ICMR), Jodhpur.
PIP: Interviews with 208 mothers of children aged under 5 years were conducted in 21 villages of Jaipur District in Rajasthan State, India, to examine the dietary practices concerning food preferences and restrictions during measles and diarrheal disease. The researcher planned to use the findings to design nutrition education programs. 83.2% of the mothers were illiterate. 80% were of low or middle socioeconomic class. 66.4% worked in agriculture or animal husbandry. Preferred foods during diarrhea were khitchri (52.4%), thuli or daliya (48.5%), banana (37.9%), and chhach/curd (21.6%). Restricted foods included roti (69.7%), milk (47.1%), vegetables, chilies, and hot foods. The major herbal medicines used to cure diarrhea were isabgol ke bhusi mixed with curd (31.3%) and extracts of tea leaves, ajwain, sonth, peepla mul, black pepper, and tulsi leaves (14.4%). Preferred foods during measles were kishmish/munakka (38.5%), khitchri/rabdi of bajra (35.6%), daliya (25%), and cow's milk (23.1%). Restricted foods included roti (62.5%), all dals except moong dal (59.1%), and vegetables (42.8%). The leading herbal medicines used to treat measles were a mixture of nutmeg, mace, clove, tulsi leaves, and kishmish (26.9%) and a mixture of nutmeg, mace, clove, tulsi leaves, and brahmi (25.5%). The mothers believed that herbal medicines save their children's lives. These findings indicate the need to consider beliefs about culturally accepted and restricted foods when designing a nutritional and health education program.
PMID: 7896375 [PubMed - indexed for MEDLINE]
3.Effect of isabgol husk supplementation in a low-fibre diet on serum levels and calcium, phosphorus and iron balance in adolescent girls.
Kawatra A, Bhat CM, Arora A.
Department of Foods and Nutrition, CCS Hayana Agricultural University, Hisar, India.
The investigation was conducted on 11 healthy, non-anaemic adolescent girls of 16-18 years of age. A balance study was conducted in two trials of 3 weeks each on low- and high-fibre diets. The high-fibre diet consisted of the low-fibre diet plus 25 g isabgol husk. The mean diet and nutrient intakes of the subjects were approximately the same during both trials. Addition of isabgol (Isphaghula) husk to the low-fibre diet significantly increased the urinary excretion of phosphorus and iron; faecal excretion of calcium, phosphorus and iron; and the serum calcium, phosphorus and iron levels decreased significantly (P < 0.05). The apparent retention of calcium, phosphorus and iron was significantly (P < 0.05) lowered on the high-fibre diet, but the balances of these nutrients were positive. Thus the isabgol does not have a desirable effect on mineral levels.
Publication Types: PMID: 8387912 [PubMed - indexed for MEDLINE]
4.Effect of Isabgol husk supplementation on trace minerals (Zn, Cu, Mn) levels in adolescent girls.
Kawatra A, Bhat CM, Arora A.
Department of Foods and Nutrition, Haryana Agricultural University, India.
The study was conducted on eleven healthy non-anaemic adolescent girls of 16 to 18 years of age. Balance studies were conducted in two trials of three weeks each on low and high fibre diets. High fibre diet contained 25 g Isabgol husk in addition to low fibre diet. The mean diet and nutrient intakes of the subjects were approximately the same during both trials. Addition of Isabgol husk to low fibre diet significantly (P less than or equal to 0.05) increased faecal excretion of zinc, copper and manganese and lowered their apparent retention. The serum levels of these trace minerals decreased significantly (P less than or equal to 0.05). Thus the high level of Isabgol has undesirable effect on trace minerals.
PMID: 1323826 [PubMed - indexed for MEDLINE]
5.Effect of dietary fibres on bioavailability of vitamin A and thiamine.
Khokhar S, Kapoor AC.
Department of Foods & Nutrition, Haryana Agricultural University, Hisar, India.
Different sources of dietary fibre (cellulose, pectin, Isabgol, cabbage and guava) were fed to weaning rats for 5 weeks to study their effect on serum vitamins. Both the plant foods (cabbage and guava) were analysed for dietary fibre. Guava was found to be a good source of dietary fibre constituting 51.77% of dry pulp, whereas cabbage contained only 16.17%. Cellulose was the major component of dietary fibre in both the plant foods. The concentration of vitamin A and thiamine in the serum of fibre-fed rats was significantly lower than that of rats on a fibre-free diet. However, the amount of vitamin A in serum decreased significantly with the increase in level of dietary fibre, but the decrease was non-significant in the case of thiamine.
PMID: 2174153 [PubMed - indexed for MEDLINE]
6.Knowledge and practices among rural mothers in Haryana about childhood diarrhea.
Sood AK, Kapil U.
Department of Preventive and Social Medicine, Medical College, Rohtak, Haryana.
Knowledge and practices of 108 rural mothers about childhood diarrhea, were determined by using pretested semi-structured interview schedules. The common causes of diarrhea reported were eruption of teeth (67.59%), eating of mud (51.85%), worm infestation (47.22%), change of climate (35.18%), poor personal hygiene (34.25%) and changes in diet (25.92%). Majority (83.33%) of mothers practiced food restriction during diarrhea. Seventy seven percent consulted their mother-in-laws in the first instance for treatment of diarrhea. The home remedies tried by mothers were, isabgol husk with curd (30.55%), ghee with tea (28.70%) water boiled with mint leaves (25.92%), local ghutti (22.22%) and unripe mango juice (16.66%). Majority of mothers (83.33%) believed that oral rehydration therapy alone, cannot treat diarrhea.
PIP: Knowledge and practice of 108 rural mothers concerning childhood diarrhea were determined by using pretested semistructured interview schedules. The common causes of diarrhea reported were eruption of teeth (67.59%), eating of mud (51.85%), worm infestation (47.22%), change of climate (35.18%), poor personal hygiene (34.25%), and changes in diet (25.96%). The majority of mothers (83.33%) practiced food restriction during diarrhea. 77% consulted their mothers-in-law initially concerning diarrhea treatment. The home remedies tried by mothers were: isabgol husk with curd (30.55%), ghee with tea (28.70%), water boiled with mint leaves (25.92%), local ghutti (22.22%), and unripe mango juice (16.66%). The majority also believed that oral rehydration therapy alone cannot cure diarrhea. author's modified
PMID: 2286409 [PubMed - indexed for MEDLINE]
7.Effect of incorporation of isabgol husk in a low fibre diet on faecal excretion and serum levels of lipids in adolescent girls.
Taneja A, Bhat CM, Arora A, Kaur AP.
College of Home Science, Hisar, Haryana, India.
The effect of consumption of isabgol husk for 3 weeks on faecal excretion and serum levels of lipids was investigated in 11 adolescent girls. The consumption of isabgol husk lowered serum lipids and increased faecal fat.
PMID: 2543555 [PubMed - indexed for MEDLINE]
8.Prevention of atheromatous heart disease.
Five thousand patients of atheromatous heart disease, presented as angina pectoris, were studied over a period of five years. After adding the 'Husk of Isabgol' and 'aloe vera' (an indigenous plant known as ghee-guar-ka-paththa) to the diet, a marked reduction in total serum cholesterol, serum triglycerides, fasting and post prandial blood sugar level in diabetic patients, total lipids and also increase in HDL were noted. Simultaneously the clinical profile of these patients showed reduction in the frequency of anginal attacks and gradually, the drugs, like verapamil, nifedipine, beta-blockers and nitrates, were tapered. The patients, most benefitted, were diabetics (without adding any antidiabetic drug). The exact mechanism of the action of the above two substances is not known, but it appears, that probably they act by their high fibre contents. Both these substances need further evaluation. The most interesting aspect of the study was that no untoward side effect was noted and all the five thousand patients are surviving till date.
PMID: 2864002 [PubMed - indexed for MEDLINE]